 Carlo Brugnara, MD
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Department/Division
Laboratory Medicine
Specialty
clinical pathology
Clinical Title
Director, Hematology Lab
Academic Appointment
Professor of Pathology, Harvard Medical School
Board Certification(s)
Clinical Pathology/Blood Banking/Transfusion Medicine
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Medical/Dental School
University of Padua (Verona) Italy, ITALY (1979)
Internship
University Hospital, Verona, ITALY (08/79 to 09/81)
Residency
Brigham and Women's Hospital, Boston, MA (07/86 to 06/89)
Fellowships
Harvard Medical School, Boston, MA (08/82 to 06/85)
Brigham and Women's Hospital, Boston, MA (07/89 to 06/90)
Membrane Biology, Ion Transport, Sickle Cell Disease, Laboratory Medicine
- Control of cell volume and determinants of cell sickling in sickle cell anemia: inhibition of red cell K+ efflux by clotrimazole, ICA17043, and oral Mg++ (J Clin Invest 97:1227, 1996; J Clin Invest 100:1847, 1997; Blood 97:1451, 2001; Am J Physiol 281:C1385, 2001; Blood 99:357, 2002; Blood 101:2412, 2003; Blood 105:382, 2004)
- Protective role of Gardos channel in HS (Blood 108:123, 2006)
- Novel therapies in sickle cell disease: use of nitric oxide (inhibits sickling), clotrimazole and Mg++ supplementation (block RBC dehydration) and hydroxurea (increases Hb F) (J Clin Invest 100:1847, 1997; J Clin Invest 100:1193, 1997; Br J Haematol 108:284, 2000; Blood 97:1451, 2001; JAMA 289:1136, 2003)
Research site for Carlo Brugnara, MD
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Primary Office Location
Children's Hospital Boston
Department of Laboratory Medicine
300 Longwood Avenue
Boston, MA 02115
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Driving Directions
Phone: 617-355-6347
Fax: 617-730-0383
E-mail
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