 Alan D. D'Andrea, MD
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Departments/Divisions
Hematology/Oncology
Medicine
Specialties
cancer susceptibility
Fanconi anemia
gene therapy
genetic risk
hematology
Services/Programs
Fanconi Anemia/Bone Marrow Failure
Hematology
Clinical Title
Co-Director, Gene Therapy Center
Academic Appointment
Alvan T. and Viola D. Fuller American Cancer Society Professor of Radiation Oncology, Harvard Medical School
Board Certification(s)
Pediatrics
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Medical/Dental School
Harvard Medical School, Boston, MA (1983)
Internship
Children's Hospital of Philadelphia, Philadelphia, PA (06/83 to 06/84)
Residency
Children's Hospital of Philadelphia, Philadelphia, PA (06/84 to 06/86)
Fellowship
Children's Hospital Boston/Dana Farber Cancer Institute, Boston, MA (06/86 to 06/87)
Fanconi Anemia, DNA Repair
- Pathophysiology of Fanconi anemia and functions of the eight known genes and gene products that cause Fanconi anemia. Linkage to BRCA1, BRCA2, NBS1 and ataxia telangiectasia DNA repair mechanisms. (Nat Genet 17:487, 1997; Proc Natl Acad Sci USA 95:13085, 1998; Blood 96:3224, 2000; Molec Cell 7:241 and 7:249, 2001; Nat Med 7:1259, 2001; Cell 109:459, 2002; Science, 297:606, 2002; Nat Cell Biol 4:913, 2002; Dev Cell 5: 903, 2003; Genes Dev 18:1958, 2004; Proc Natl Acad Sci USA 102:1110,2005)
- Some tumors increase their mutagenic rate by somatic mutations that disrupt the Fanconi pathway (Nat Med 9:568, 2003), but may revert and become chemotherapy resistant (Cancer Res 15:2688, 2003)
- Deubiquinating enzymes regulate Fanconi pathway (Mol Cell 17:331, 2005; Nat Cell Biol 8:339,2006
Research site for Alan D'Andrea, MD
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Primary Office Location
Dana-Farber Cancer Institute
Department of Pediatric Oncology
44 Binney Street
Boston, MA 02115
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Driving Directions
Phone: 617-632-2112
Fax: 617-632-5757
E-mail
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