 George Daley, MD, PhD
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Departments/Divisions
Hematology/Oncology
Medicine
Services/Programs
Fanconi Anemia/Bone Marrow Failure
Hematology
Oncology
Stem Cell Transplantation
Clinical Titles
Samuel E. Lux IV Chair in Hematology
Director of Stem Cell Transplantation
Associate Chief, Division of Pediatric Hematology/ Oncology
Children's Hospital and Dana Farber Cancer Institute
Academic Appointment
Associate Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
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College
Harvard University , Cambridge , MA (1982)
Graduate School
Ph.D., MIT, Cambridge, MA (1989)
Medical/Dental School
Harvard Medical School , Boston , MA (1991)
Internship
Mass General Hospital , Boston , MA (1991-92)
Residency
Mass General Hospital , Boston , MA (1992-95)
Fellowships
Research Fellowship, Whitehead Institute for Biomedical Reseach (1995-2003)
Clinical Fellowship Hematology/Oncology, Children's Hospital Boston, Dana Farber Cancer Institute, and Brigham Women's Hospital, Boston, MA
Whitehead Institute for Biomedical Research, Cambridge , MA (1995-2003)
The laboratory focuses on stem cell biology, with an emphasis on somatic cell reprogramming, hematopoietic differentiation from human and mouse pluripotent stem cells, germ cell development, and mechanisms of oncogenesis. Our specific research programs are described briefly below:
Directed differentiation of HSCs from pluripotent stem cells: We study hematopoietic development in mouse embryos and differentiating cultures of human and mouse pluripotent stem cells to define the molecular genetic programs that enable formation of HSCs in experimental and therapeutic models. Our long-term goal is improved transplantation therapies for genetic and malignant blood disorders. (Nature 459:1131, 2009; Nature 460:259, 2009; Blood 114:268, 2009)
Derivation of genetically defined pluripotent stem cells: We use nuclear transfer, parthenogenesis, and reprogramming with defined genes to model combined cell and gene therapy of human genetic disorders. (Cell 134: 877, 2008; Nature 451:141, 2008)
Germ cell development and germ cell tumor biology: We have devised methods for directed differentiation of pluripotent stem cells into primordial germ cells in vitro, which provides an accessible in vitro model system for studying germ lineage commitment. We are studying genetic pathways that preserve pluripotency in the germ lineage and which become deranged in germ cell tumors. (Nature online July 5, 2009; Nature 427:148, 2004; Science 316:409, 2007)
Mechanisms of oncogenesis: We have a long-standing interest in molecular mechanisms of leukemia induction by the BCR/ABL oncoprotein in human Chronic Myeloid Leukemia, the classic malignancy of hematopoietic stem cells. Recent studies in our lab have identified novel genes involved in CML progression to blast crisis. (Nature 41:843, 2009; Cell 112:831, 2003, Nat Struc Mol Bio 15:1109, 2008)
Research site for George Daley, MD, PhD
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