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Stuart H. Orkin, MD

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Departments/Divisions
 Hematology/Oncology
Medicine

Specialty
 hematology

Services/Programs
 Hematology
Oncology

Clinical Title
 Chairman, Pediatric Oncology

Academic Appointment
 David G. Nathan Professor of Pediatrics, Harvard Medical School

Board Certification(s)
 Pediatrics
 

Professional History
 
Medical/Dental School
 Harvard Medical School, Boston, MA (1972)

Internship
 Children's Hospital Boston, Boston, MA (07/72 to 06/73)

Residency
 Children's Hospital Boston, Boston, MA (07/74 to 06/76)

Fellowship
 Children's Hospital Boston, Boston, MA (07/76 to 06/78)

Research Activities

  • Developmental Biology of Blood, Blood Vessels and Heart, Cancer Biology, Stem Cell Biology
    • Role of GATA-1, GATA-2 and other transcription factors (SCL, NF-E2, EKLF, BKLF, RBTN2, VAV, TEL, SHP﷓2, SP1) in mammalian blood cell and blood vessel formation (Nature 374:470, 1995, Nature 375:318, 1995, Cell 86:47, 1996; Cell 90:109, 1997; Genes Dev 12:473, 1998; Genes Dev 12:2392, 1998; Nat Genet 24:266, 2000; Genes Dev 16:301,2002; J Exp Med 195:1387, 2002 and 197:281, 2003; Immunity 18:109, 2003; Proc Natl Acad Sci USA 100:14030, 2003; Genes Dev 18:2336, 2004)
    • Role of GATA factor-interacting proteins in blood and heart development (Cell 90:109, 1997; Cell 101:729, 2000; Genes Dev 15:839, 2001)
    • Platelet formation (Cell 81:695, 1995; Genes Dev 12:1176, 1998; Mol Cell Biol 22:4268, 2002; Proc Natl Acad Sci USA 99:9237, 2002)
    • Control of globin transcription (Proc Natl Acad Sci USA 97:7172, 2000)ยท Function of peroxiredoxin (Nature 424: 561, 2003)
    • Role of GATA-1 mutations in transient myeloproliferative syndrome of Down's neonates (Nat Genet 37:613, 2005)
    • Factors involved in stem cell formation and function and stem cell niches (Nature 421:547, 2003; Nature 431:1002, 2004; Dev Cell 8:365, 2005)

     
  • Research site for Stuart Orkin, MD
     
  • Molecular Hematopoiesis, Cancer and Stem Cell Biology (some recent papers)
    • Hematopoiesis: Roles of transcription factors in development and function of hematopoietic stem cells and progenitors (Proc. Natl. Acad. Sci. USA 103:9057,2006; J. Biol. Chem. 281:13733, 2006; Blood 107:3527,2006; Dev Cell 8:365,2005
    • Leukemia: Roles of somatically mutated transcription factors in human leukemias (Nat Genet. 37:613, 2005; Proc. Natl. Acad. Sci USA 103:3339, 2006)
    • Stem Cell Biology: Studies of hematopoietic stem cells and embryonic stem cells (Cell 122:828, 2005; Nature 431:1002, 2004; Genes Dev 18:2336, 2004

    • Previous | Next | Return to Search Results




    Stuart H. Orkin, MD  
       

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     Dana-Farber Cancer Institute
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