 Alan B. Cantor, MD, PhD
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Departments/Divisions
Hematology/Oncology
Medicine
Specialty
hematology/oncology
Services/Programs
Fanconi Anemia/Bone Marrow Failure
Hematology
Thrombocytopenia
Clinical Title
Assistant in Medicine
Academic Appointment
Assistant Professor of Pediatrics, Harvard Medical School
Board Certification(s)
Pediatric Hematology/Oncology
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College
Cornell University, Ithaca , NY (grad. 1985)
Graduate School
Washington University School of Medicine, St. Louis , MO (PhD 1993)
Medical/Dental School
Washington University School of Medicine, St. Louis, MO (1993)
Internship
Pediatrics, Saint Louis Children's Hospital, St. Louis, MO (07/93 to 06/94)
Residency
Pediatrics, Saint Louis Children's Hospital, St. Louis, MO (07/94 to 06/96)
Fellowship
Pediatric Hematology/Oncology, Children's Hospital Boston/Dana-Farber Cancer Institute, Boston, MA (07/96 to 06/98)
Alan Cantor's laboratory is focused on further elucidating the transcriptional mechanisms that regulate normal hematopoiesis and how they may be perturbed in certain hematologic malignancies and myelodysplastic syndromes. Cantor and colleagues are particularly interested in the role of GATA, FOG, RUNX and ETS transcription factor family members in megakaryocyte development and platelet production.
The Cantor laboratory is currently taking three approaches to further understand the roles of these transcription factors in megakarkyopoiesis and hematologic malignancy. The first is to isolate and characterize stable multiprotein complexes involving these factors. The second approach involves genome-wide identification of target genes of these factors (and their cis-regulatory elements) by a chromatin immunoprecipitation-DNA sequencing techniques. The third approach involves human genetic studies of families with inherited thrombocytopenias and propensity for the development of myelodysplastic syndrome and leukemia.
Transcription Factors in Erythropoiesis and Megakaryopoiesis
- Characterization of FOG-2 protein, a GATA-family cofactor (Proc Natl Acad Sci USA 96:950, 1999).
- Domains of FOG-1 that control erythroid, eosinophilic and megakaryocytic differentiation. (Proc Natl Acad Sci USA 99:9237, 2002; J Exp Med 195:1387, 2002; Mol Cell Biol, 22:4268, 2002; 22:3121, 2002; Immunity 19: 451, 2003)
- Cofactors regulating GATA-1 interactions with chromatin (Proc Natl Acad Sci 101: 980, 2004)
Johnson, Kirby D, Boyer, Meghan E, Kang, Jeong-Ah, Wickrema, Amittha, Cantor, Alan B, Bresnick, Emery H. Friend of GATA-1-independent transcriptional repression: a novel mode of GATA-1 function. Blood 109:5230-3, 2007.
Research website for Alan Cantor, MD, PhD
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