 Barry H. Paw, MD, PhD
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Departments/Divisions
Hematology/Oncology
Medicine
Service/Program
Oncology
Clinical Title
Assistant in Medicine
Academic Appointment
Assistant Professor in Medicine, Harvard Medical School
Board Certification(s)
Pediatrics, Pediatric Hematology/Oncology
Year Appointed
1991
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College
A.B., Biochemistry, University of California, Berkeley, Berkeley, CA (1984)
Graduate School
Ph.D., Biological Chemistry, University of California, Los Angeles School of Med, Los Angeles, CA (1991)
Medical/Dental School
M.D., Medicine, University of California, Los Angeles School of Medicine, Los Angeles, CA (1991)
Internship
Pediatrics, Children's Hospital Boston, Boston, MA (1991-1992)
Residency
Pediatrics, Children's Hospital Boston, Boston, MA (1992-1993)
Fellowship
Pediatric Hematology-Oncology, Children's Hospital Boston and Dana-Farber Cancer Institute, Boston, MA (1993-1996)
The general focus of our group centers on the developmental biology of hematopoiesis (blood). Current projects include genetic screens to study red cell and platelet development and genetic mapping for candidate and positional cloning. Functional studies of cloned genes are studied in zebrafish embryos and complementary model systems, such as mouse (cultured cells and transgenic mice) and yeast. One particular research centers on the first vertebrate mitochondrial iron-importer required for erythropoiesis, mitoferrin [scl25a37] (Nature 2006 440:96-100).
http://paw-lab.bwh.harvard.edu/index.html
Hematopoises and Iron Metabolism
- Genetic Screens in zebrafish for mutations affecting erythropoiesis (Development 127:5123, 2000; Development 129:4359, 2002; Nat. Genet. 34:59, 2003; Proc. Natl. Acad. Sci. USA 105:3333, 2008)
- Mitochondrial iron metabolism using zebrafish, mouse, and cell culture models (Nature 436:1035, 2005; Nature 440:96, 2006; Cell Metabolism 10:1, 2009; Proc. Natl. Acad. Sci. USA 2009, in press)
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