 David A. Williams, MD
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Department/Division
Hematology/Oncology
Specialties
blood formation
blood stem cell biology
Fanconi anemia and bone marrow failure
gene therapy
genetic blood disorders
Services/Programs
Fanconi Anemia/Bone Marrow Failure
Hematology
Oncology
Clinical Titles
Chief, Division of Hematology/Oncology
Director of Translational Research
Academic Appointment
Leland Fikes Professor of Pediatrics, Harvard Medical School
Board Certification(s)
Pediatrics
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Medical/Dental School
Medicine, Indiana University School of Medicine, Indianapolis, IN (1979)
Internship
Pediatrics, Cincinnati's Children's Hospital Medical Center, Cincinnati, OH (1980)
Residency
Pediatrics, Cincinnati's Children's Hospital Medical Center, Cincinnati, OH (1982)
Fellowship
Hematology/Oncology, Children's Hospital Boston/Dana-Farber Cancer Inst, Boston, MA (1985)
Dr. Williams major research interests are in the study of blood stem cell biology, blood formation, leukemia and the treatment of genetic blood diseases using gene therapy. He has published over 200 peer-reviewed manuscripts and textbook chapters. He was an investigator of the HHMI for 16 years. He has been continuously funded by the NIH since 1986. His laboratory co-discovered and cloned Interleukin-11 (Neumega) and carried out developmental studies that assisted in obtaining FDA approval of this drug. His laboratory also described the use of fibronectin in retrovirus-mediated gene transfer, now nearly universally used (as Retronectin) in clinical gene therapy trials and basic research utilizing gene transfer. He and Dr. Yi Zheng have developed a new small molecule inhibitor of Rac GTPases that is being investigated collaboratively with Amgen as a molecular target in cancer therapies. Thus, work in the Williams laboratory has led to multiple patents and product licenses for new therapies in human diseases.
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