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Leonard I. Zon, MD

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Departments/Divisions
Hematology/Oncology
Medicine

Specialties
aplastic anemia
congenital anemias
hematology

Services/Programs
Fanconi Anemia/Bone Marrow Failure
Hematology

Clinical Title
Associate in Medicine

Academic Appointment
Grousbeck Professor of Pediatrics, Harvard Medical School

Board Certification(s)
Internal Medicine, Hematology

 

Professional History
 
Medical/Dental School
Thomas Jefferson University, Philadelphia, PA (1983)

Internship
New England Deaconess Hospital, Boston, MA (07/83 to 06/84)

Residency
New England Deaconess Hospital, Boston, MA (07/84 to 06/86)

Fellowship
Dana-Farber Cancer Institute, Boston, MA (07/86 to 06/89)

Research Activities

  • Research site for Leonard Zon, MD
     
  • Stem Cells, Developmental Baiology of Blood and Blood Vessels, Cancer Genetics in Zebrafish
    • Characterization of genes required to form stem cells (Nature 425:300, 2003)
    • Characterization of genes required for formation of blood cells and blood vessels from mesoderm in zebrafish and frogs (Nature 382:357, 1996; Immunity 7:325, 1997; Genes Dev 12:621, 1998; Development 125:2611, 1998; Development 128:2301, 2001; Development 129:649, 2002 and 129:4359, 2002; Science 295:457, 2002; Cell 108:731, 2002; PLoS Biol. 2:E237, 2004; Dev Cell 8:109, 2005; Genes Dev 19:2331, 2005)
    • Characterization of models of human anemias in zebrafish (Nat Genet 20:244, 1998; Development 127:5123, 2000; Nature 403:776, 2000; Nat Genet 34: 59, 2003; Development 131:6225, 2004; J Clin Invest 115:1532, 2005)
    • Identification of new genes involved in iron transport and hemoglobin formation. (Nature 403:776, 2000; Blood 100:4655, 2002; J Clin Invest 115:1532, 2005; Nature 436:1035, 2005; Nature 440:96, 2006
    • Cancer genetics using zebrafish (Cancer Cell 1:229, 2002; Science 299:887, 2003; Proc Natl Acad Sci USA 102:407, 2005; Curr Biol 15:249, 2005; Proc Natl Acad Sci USA 102:13194,2005)
    • Role of SUMOylation and the promyelocytic leukemia (PML) gene in transcription (Mol Cell 10:831 and 10:843, 2002)
    • Transplantation and in vivo imaging in zebrafish (Nat Immunol 4: 1238, 2003)
    • T cell development in zebrafish (Immunity 20:367, 2004; Proc Natl Acad Sci USA 101:7369, 2004)
    • Hematopoietic stem cell transplantation in zebrafish (Blood 104:1298, 2004)
    • Chemical suppresor screens (Nat Chem Biol 1:366, 2005)

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    Leonard I. Zon, MD  
       

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    Children's Hospital Boston
    Division of Hematology/Oncology, Karp 7
    300 Longwood Avenue
    Boston, MA  02115
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